Francis Shackelford
- Date of birth: 1664
- Place of birth: ?
- Date of death: 1726
- Father: John Shackleford
- Mother: ?
- Marriage: ?
- Children:
- Absalom Shackelford
- Armstead Shackelford
- Betsey Shackelford
- Henry Shackelford
- John Shackelford
- Nancy Shackelford
- Rebbecca Shackelford
- Abner Shackelford